The artificial sweetener saccharin can disrupt the gut microbiome in detrimental ways, increasing inflammatory cytokines.

“There was a study that showed that artificial sweeteners, but a particular artificial sweetener, which was saccharin, can disrupt the gut microbiome in ways that is detrimental to a number of different health markers.”

“I've seen some literature that points to the possibility that they might be, "bad for the gut microbiome."”

“it's saccharin that is showing a lot of the adverse potential. So, for example, the negative effects on gut microbiome that have led to impaired glucose tolerance in humans over a short period of time...”