Crisco, a hydrogenated vegetable oil product, was a known cause of heart attacks.

“Crisco is a great example. Crisco was invented in 1911. It was shortening because there was a butter shortage. And so they basically created this product, which is blowing hydrogen atoms into liquid vegetable oil that makes it act like an animal fat, like lard or butter. And it was cheap, and it was good. So it was in the supply from 1911 to 2015. It wasn't until 50 years after the data started to become clear that this was a cause of heart attacks, that this was very dangerous-- we shouldn't be eating margarine.”