Humans transitioned from plant hunting to animal hunting, leading to biochemical and physiological adaptations where plant toxins became more impactful.

“I don't think that there's been any selective pressures or any significant selective pressure to allow for human evolution with plants to tolerate those toxins in the last million years of Homo evolution meaning the Homo genus evolution whether it's Homo sapiens Homo erectus Homo habilis whatever like I would argue that we have not to be there have not been selective pressures for us to need to eat plants in that way so we probably cannot tolerate those toxins”

“we became I would argue animal hunters instead of plant hunters and with that transition from plant hunting to animal hunting there were transitions in terms of our biochemistry our adaptation to eating plans and it seems that the plant toxins began to affect us much and much more than they had before”