Rhonda Patrick· PhD
We know if we put athletes on a treadmill or bike in a hypoxic environment and give them glucose, that the performance-enhancing effects of glucose are not observed in hypoxia, which is kind of, you know, interesting. Whereas it's also shown that there may be an inhibition under hypoxic environments of pyruvate dehydrogenase. There might be some PDH deficiency or some snag or bottleneck in the metabolic pathway associated with glycolytic energy production under hypoxia.