The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
this receptor for leptin leptin receptor the the functional form of it is expressed almost exclusively in the brain and it's expressed in all of the brain regions that we knew from previous work were important for appetite so basically the expression of this receptor gives you a map in the brain of the neurons that control hunger
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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if you knock them out of gabaergic cells you get a really big basically you recapitulate animals that don't have the leptin receptor at all in terms of their body weight
there was a paper suggesting you can just knock it out of agrp neurons and get um and recapitulate the obesity phenotype of animals that have no leptin receptor