Peter Attia· MD
So, um, we know, for example, that when people lose significant amounts of weight, they're usually losing lean tissue as well. It's one of the tradeoffs. And in some people, it's a totally reasonable trade-off. You know, you see somebody who's already got an appendicular lean mass index at the 90th percentile and their fat mass index is at the, you know, 99th percentile, you you'll, you know, you're going to have them lift like crazy during weight loss because you want to keep that lean mass up. Maybe it falls to 70th or 80th percentile while you try to get fat mass index down to 60th or 70th percentile. So, what about the impact on BMD? Well, there's no question that the correlation between weight loss and a decrease in BMD, exactly what we don't want to see in the obese and in particular in the elderly is very strong.