Genome-wide association studies on body mass index are largely related to the brain, while studies on body fat distribution show a stronger insulin signaling component.

“so all of those are heavily enriched for brain related genes to a similar degree so conditions that we know are related to the brain like educational attainment how you know how how many years of education you've attained whether you are susceptible to schizophrenia depression tourettes like all these brain related conditions obviously the brain shows up in genome-wide association studies for those conditions and you put those next to body mass index and you couldn't tell them apart like that's how heavily enriched for brain related biology body mass indexes”

“if you look at genome-wide association studies on body mass index they're all about the brain largely about the brain if you look at genome-wide association studies on body fat distribution so you're getting rid of the bmi you're controlling for bmi and you're saying where is that fat on the body those have more of an insulin signal so insulin pops up pretty prominently in those”

“if you look at body mass index it looks like psychiatric diseases and educational attainment so all all of those are heavily enriched for brain related genes to a similar degree”