The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
however if you look at the monogenic obesity syndromes so where there's one mutation that causes severe obesity those really revolve around the leptin brain signaling axis so those mutations tend to be in leptin the leptin receptor melanocortins melanocortin receptor that are downstream of leptin in the brain
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
leptin and the leptin receptor in terms of mutations in those genes do not account for the vast majority of obesity very rare
if you look at the monogenic Obesity syndromes so where there's one mutation that causes s obesity those really revolve around the leptin brain signaling axis so those mutations tend to be in leptin the leptin receptor melanocortin melanocortin receptor that are Downstream of leptin in the brain