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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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Is obesity hereditary? | Peter Attia & Wendy Chung — Whalespan

Content›Video›Is obesity hereditary? | Pet…

Is obesity hereditary? | Peter Attia & Wendy Chung

Peter Attia8m · 2023-09-02

Claims Made

16

Claims Supported

10

Support Rate

63%

Support rate

10 of 16 claims supported

10 supported6 partial / not

Claims from this content

11

✓Well SupportedThe heritability of obesity is approximately 75%.◐Partially SupportedMonogenic obesity syndromes involve mutations in the leptin-brain signaling axis, including leptin, the leptin receptor, or downstream melanocortins.◐Partially SupportedStatins work across various genetic mechanisms for hypercholesterolemia.✓Well SupportedEpigenetics involves chemical modifications to the genome, such as methylation, that affect gene regulation and can change dynamically over a lifetime and by cell type.Partially Supported

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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◐

Chemical modifications like methylation affect gene regulation and are dynamic, varying by life course and cell type.

◐Partially SupportedCalorically dense foods and physical activity levels significantly influence obesity rates in genetically similar populations.

◐Partially SupportedMaternal dietary folate levels during pregnancy affect the epigenetics of offspring, influencing coat color and obesity.

◐Partially SupportedUnderstanding the final common biological pathway for regulating body weight could lead to permanent genetic or pharmacological interventions for obesity or cardiovascular disease.

◐Partially SupportedType 1 diabetes involves a complex interaction between the immune system and environmental exposures.

◐Partially SupportedEpigenetic profiles from blood samples may not accurately reflect the epigenetic state of other tissues.

◐Partially SupportedFolate is utilized in DNA methylation.