The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
the work of Charley Siran at the Brigham is showing that the way that we resolve inflammation our understanding of it is really I think in the learning to crawl stage and so if you look at the omega-3 6 pathway in the body fish oils can help you know kind of push the reactions in a particular direction but typically they're not enough for the resolution of inflammation
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EPA definitely gives rise to molecules that are pro of resolution of inflammation so inflammation starts the EPA will will shut it down to whatever extent a cardiovascular event is is precipitated by an inflammatory event the omega-3 EPA could could participate in that it could stop it
when omega-3s are metabolized their byproducts play a role in managing inflammation these byproducts are called spms specialized pro-resolving mediators these spms promote apoptosis regulate leukocyte activity and reduce the production of pro-inflammatory molecules this is important for heart health because inflammation is a key driver in cardiovascular disease
so they're pro-resolving mediators they're molecules made from epa and dha that and some that are made from arachidonic that are also suppressive lypoxin a this is the one from arachidoni so that whole field of um it isn't just that they're anti-inflammatory they're pro-suppression pro-suppressing of inflammation which is the important piece right
I mean there's there's some clinical studies showing that you know these SPMs are you know they're they're in the bloodstream pretty immediately after taking them and they can last like 24 hours
And again, you know, omega-3 fatty acids are doing just that. They are suppressing inflammation. They're resolving inflammation. They are doing it through a variety of mechanisms. They have these specialized pro-resolving mediators that are really keeping the immune response in check.