Women genetically predisposed to breast cancer who took 5 grams/day of EPA/DHA omega-3 fish oil for 6 months showed hypomethylation in TNF-alpha and decreased pro-inflammatory pathways.

“The study was, like, women that were genetically predisposed to breast cancer, they were given 5 grams a day of fish oil. So, it was EPA, DHA omega-3, the marine omega-3 fatty acids, and this was like 6 months treatment. And, like, they had done some sort of methylation profiling, not epigenetic clock but profiling of their blood, PBMC's, their peripheral blood mononuclear cells. And there was like hypomethylation in I think it was like TNF-alpha or one of the major controllers of inflammation where it was like decreasing a lot of the pro-inflammatory pathways.”