The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
Some of the the most well-known mechanisms um do have to do with the the omega-3 fatty acids being very powerful regulators of the inflammatory process in some way, shape, or form. Whether that has to do with resolins that are produced, so these from the metabolites uh of like DHA for example, resolins play a role in resolving inflammation.
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And so the omega-3 fatty acids like DHA and EPA which are in Lvesa or Levaza are what the metab they're when they're metabolized they're forming these molecules resolins protectins these things are resolving inflammation and so I think that um it's just it's one of the easiest ways that you can you can increase your anti-inflammatory response
so you know my the way I personally think about both EPA and DHA so there there's a variety of metabolites and of DHA um that are involved in resolving inflammation so these are resolvin the marison the spms protectant and EPA also has uh some of those metabolites as well and it also plays a direct role in inflammation through the sort of um I don't want to say inhibition but like dampening the prostaglandins and the lucrin and a lot of the other inflammatory processes
And of course, Professor Serhan [SP] from Harvard has shown that resolution is a critical part. You have the inflammatory part but then you have to have the resolution part. And if you don't have that resolution part, again, a change in mode, then you're stuck with this chronic inflammatory state. And so things like omega-3s and omega-3 derived maresins and things like that are actually involved with the resolution, resolvins, named for that very event.
The Omega three fatty acids, EPA, and DHA support an effective immune system by helping to resolve the inflammatory response after the infection. Inflammation, a key part of the immune response is an influx of fluid immune cells and other mediators that function to eliminate the infection. After the immune response, the Omega three fatty acids, EPA and DHA present at the inflammation site are enzymatically converted to specialized pro resolving mediators known as resolvants, protectants and marezines. These molecules, along with others function together to orchestrate the resolution of inflammation and to support healing, including in the respiratory track.
not just anti-inflammatory they're pro-resolving of inflammation yes which is the flip side of you know you can you can either prevent an inflammation from starting which may not be good because inflammation at one level is important but if you don't have the omega-3s on board the active process of shutting down the inflammation once it starts that shutdown is inhibited so the inflammation stays longer
But, you know, I mean, the anti-inflammatory resolving inflammation in so many different ways. I mean, there's like the specialized pro-mediating molecules. There's the resolvans, the protectins, the maresins. I mean, it's doing...you know, it isn't just prostaglandins. It's not just, you know, this one, you know, pathway. I mean, it's doing a lot of things.
omega-3 transport has been shown mechanistically at least in animal studies to regulate blood-brain barrier function through the mfsd2a transporter and um it's also like many of the metabolites of both DHA and EPA the Marine omega-3 fatty acids are involved in resolving inflammation so they have resolvins they have the specialized pro-mediating molecules the spms and the marisens
It's also the metabolites of EPA and DHA are these specialized pro-mediating... They're specialized pro-resolving molecules. And so they resolve inflammation in a very efficient and timely manner. These are the mericins, the protectins, the SPMs, the resolvins.
So both EPA and DHA, they get metabolized and their metabolites help resolve inflammation. So if we're looking at EPA, they make resolins, the E the E series of resol resolins. DHA makes the D series, but it also makes the protectins and the neuroprotectins.