Andrew Huberman· PhD
a good option here are things like Omega-3s um good evidence some somewhere in the neighborhood of like 2 to 5 GRS total typically like a 1:1 um EPA to DHA ratio is fine
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
a good option here are things like Omega-3s um good evidence some somewhere in the neighborhood of like 2 to 5 GRS total typically like a 1:1 um EPA to DHA ratio is fine
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so it's essentially it's four weeks before you know you see that kind of significant change and then it plateaus off between six and eight weeks
and with that dose it typically will level off we've seen this in the FAFSA paper we did with this use atrophy it wasn't you know the primary aim of the paper but between six and eight weeks it seemed to to level off um and this is in the muscle phospholipid profile
if you take around five grams of Omega-3s three grams of EPA two grams of DHA say as a combination you'll probably see a small change after about two weeks um in the muscle you see a rapid change in the blood but it takes around four weeks before you start to see the kind of big difference
it takes about four weeks for the DHA to accumulate in the skeletal muscle so it's not it's not like the anti-inflammatory effect of which is like instant right so it's a little bit different
so um the question is like what type of Omega-3 was involved and then disuse atrophy study coming out of Dr Chris MC glor's Lab at um Queens University uh so it was the marine forms of Omega-3 so it was EP PA and DHA I don't know off the top of my head the ratio but they were pretty similarish
it takes about one month for Omega-3s to accumulate in cell membranes including in cell your your skeletal muscle cell membranes
That's how long it takes to accumulate in cell membranes.
So take so that's why they preloaded them for one month with with five grams of omega-3 and then they immobilized their leg.