The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
Astronauts in microgravity, they lose one to 1.5% of their bone mineral density per month, 10 times faster than people on Earth because they don't have they're not doing the the loadbearing exercises. They're not putting their bones to work in microgravity.
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A loss of load leads to bone mineral loss. For example astronauts in microgravity can lose up to 1 to 1.5% of their bone density per month, which is 10 times faster than what you'd experience on Earth.
it's not enough it's weightbearing loading that is important and we know this because of how much bone people lose if they go into microgravity