HNE is a normal signaling molecule that signals repair and the need for angiogenesis, but can also cause decoupling of mitochondrial energy production and is a leading cause of DNA damage.

“it is highly toxic it is also a normal signaling molecule I mean Peter at hyperlipid has been on a charge lately talking about reactive raws reactive oxidation species and decoupling hne is one of two things that causes that decoupling there's palmitic acid and then there's hne which seems to be because when it is produced in the mitochondria it's a signal that something is going wrong and it says okay guys you know put the clutch on run the engine but let's disconnect the wheels until we figure out what the heck is going on here um it also is a primary appears to be a leading cause of DNA damage as seen in cancer”