Dutasteride reduces DHT levels by approximately 95%, potentially causing side effects like reduced sex drive, reduced overall drive, increased estrogen and prolactin, and gynecomastia.

“It's just near flatlines DHT, and that can occur at concentrations as low as 0.5mg, although you will see prescriptions and people taking d utasteride anywhere from 0.5 mg all the way to 2.5mg orally. Now, not surprisingly, dutasteride is associated with a lot of side effects related to the DHT pathway. Things like reduction in sex drive, reduction in overall drive, it also tends to impact other hormone pathways, so it increases in estrogen prolactin. That's why gynecomastia, growth of male breast tissue sometimes occurs when people take dutasteride.”