The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
The bottom line is, I think all cancers require some amount of PI3-kinase to survive. And so if we can keep the insulin level low, and insulin, of course, is the best way to activate PI3K, if you can keep the insulin level low and now turn off PI3K, you don't get that rebound of insulin and the tumors just go away.
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
But the bottom line was, there was a benefit in every single cancer we looked at.
So if you did a run-in to the ketogenic diet, so they have an entire week on the diet, and then they're given the inhibitor, it's incredibly effective because by then you've depleted all the glycogen, all the relevant tissues.
And in the context of insulin suppression with a ketogenic diet, that can unmask and augment and greatly enhance PI3 kinase inhibitors.