Peter Attia· MD
So, um, the only So, so I want to be clear, I don't think this was the world's best, um, MR. I think it was clever, though. So, what did they look at? Cuz like what genes would you try to parse out to understand how much tobacco someone is consuming, which is what you actually want to be able to do. So what they looked at was they looked at genes that spoke to nicotine metabolism. And so just as caffeine, we've talked about this in the past, caffeine metabolism is highly genetic, right? So people like me are wickedly fast at metabolizing caffeine um and therefore I seem to be able to drink it later in the day without a negative impact. Um someone who's a very slow metabizer is going to feel it more. Well, similarly with nicotine, you have high and low levels of nicotine um metabolism. And what the authors of this study uh postulated was people who are um faster nicotine metabolizers are going to have lower levels of circulating nicotine and therefore less nicotine exposure.