Xenobiotic metabolizing enzymes exhibit significant sex-specific differences in activity between males and females.

“the enzymes that the liver uses to deal with foreign drugs these are called enzymes of xenom metab xenobiotic metabolism xenobiotic metabolizing enzymes are radically different between men and women and between male and female mice most of them not all but most of them are a lot higher in females but some are a lot higher in males and this is also true for people so the pace at which drugs are conjugated put into the bile or put into the urine or excreted in the feces or excreted in the urine very often are sex specific”

“when you talk about the difference in the pharmacokinetics between male and female mice we can only extrapolate and say that our you know cytochrome p450 system as humans must have sex differences oh yeah that's well documented absolutely”