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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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Successful lifespan molecules tested by the ITP | Peter Attia & Rich Miller — Whalespan

Content›Video›Successful lifespan molecule…

Successful lifespan molecules tested by the ITP | Peter Attia & Rich Miller

Peter Attia7m · 2023-12-05

Claims Made

15

Claims Supported

13

Support Rate

87%

Support rate

13 of 15 claims supported

13 supported2 partial / not

Claims from this content

10

✓Well SupportedEncapsulated rapamycin was effective in extending lifespan in both late middle-aged and younger mice.✓Well SupportedPharmacologic inhibition of mTOR with rapamycin or its analogs shows promise for lifespan and healthspan improvement, even when initiated late in life.✓Well SupportedCuring all cancers would increase life expectancy for a typical 50-year-old US woman by approximately three years.✓Well Supported17-alpha-estradiol, acarbose, and canagliflozin have shown lifespan extension benefits in mice even when started in middle or old age.Partially Supported

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Peter Attia on Rapamycin (with Matt Kaeberlein)

Attia walks back the clinic protocol: too aggressive for healthy adults

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

◐

Xenobiotic metabolizing enzymes exhibit significant sex-specific differences in activity between males and females.

◐Partially SupportedA hypothetical drug that abolishes all heart attacks in people over 50 would increase median human lifespan by less than 3%.

◐Partially SupportedThere is a lack of comprehensive pharmacokinetic data regarding drug differences in human sexes, which should inform dosing recommendations.

◐Partially SupportedAcarbose is primarily active in the gut and not significantly absorbed systemically.

◐Partially SupportedAcarbose's greater efficacy in male mice may be due to their higher sensitivity to glucose spikes, which acarbose mitigates.

◐Partially SupportedCanagliflozin was not beneficial for females in ITP studies, possibly due to toxic drug concentrations.