Encapsulated rapamycin was effective in extending lifespan in both late middle-aged and younger mice.

“Rapa lengthens mouse lifespan in multiple studies.”

“Rapa lengthens mouse lifespan in multiple studies.”

“In 2009 a study in older mice showed that dosing rapamy increased lifespan for females 14% and males 9% When they repeated the study in younger mice they showed that rapamy further increased longevity Now when they combined rapamy with other drugs such as a carbos they showed even further longevity benefits In females it was 28% in males it was 34%”

“Rapamycin extends lifespan in mice - https://t.co/lE1qLwubLs”

“what was interesting in the mice as they started late in life they started at 600 days which is that's about 60 years old yeah that's that's like starting is with this room that was really late in life for the my yeah yeah I was Wow made it that much more impressed”

“we did do a lower dose for three months as well and there we saw increases in lifespan in both males and females roughly the same magnitude so it was that dose was nine times higher than what the ITP tested”

“so it was that dose was nine times higher than what the ITP tested well”

“in 2009 this mouse study comes out it was the first of what would become a series of very interesting highly reproduced itps funded by nih that sort of did something we didn't typically see which is consistently across multiple labs and across different strains show the same result”

“we had in 2012 at least three or four years of very good evidence that rapamycin could be beneficial to extend lifespan through the itps so the interventions testing programs run through nih there had been several indications either directly through administration of rapamycin or indirectly through genetic inhibition of mtor that you could extend the life of yeast worms flies and mice”

“and the rapa solo which joan is pretty impressive as well was i believe 16 and 9 by gender right”

“yes then that was the first drug that gave a very strong signal in both males and females and it's still the only drug that we've tested so far which gives a very strong signal in females”

“the median extension which we've already said not as interesting that's just saying what's the age at which half the animals have died and the males went up 20 percent and the females that went up 13”

“the ones i've have ingrained in my head and maybe i hope i have them right is the the p90 life lifespan extension which in males was nine percent in females was 14”

“the maximum extension in males went from 9 to 11 percent and in females it went from 14 to 16”

“the ITP was the first study that really put rapid mice on the map in 2009 that was the study that's fortuitously demonstrated that even when ravamycin was given very very late in life it was given to 60 month old mice it still afforded them a 15 lifespan extension”

“yeah well Rapa uh in in our 2009 paper had a really big effect uh at we picked a dose um that seemed like it it might work and it did it's not the optimal dose it's less than the optimal dose but it's the dose we chose both males and females had a significant lifespan extension”

“in both sexes starting as late as 20 months of age does not diminish the um uh ability of the drug to extend lifespan”

“rapy um in that first paper was also the first drug I believe where anyone had showed we we found that it works quite well even if you start in really old mice some of the mice that were exposed in that paper didn't start until 20 months of age where the median survival is about 24 for males and 26 for females”

“yeah well Rapa uh in in our 2009 paper had a really big effect the dose we chose both males and females had a significant lifespan extension”

“uh in in our 2009 paper had a really big effect uh at we picked a dose that seemed like it it might work and it did it's not that optimal dose it's less than the optimal dose but the dose we chose both males and females had a significant lifespan extension to put this into perspective these drugs are giving at the M middle dose 15 to 20% increase in median lifespan”

“when Randy finally with his colleagues figured out how to make the protected version the encapsulated version of Rapa mice and we actually used it twice the same batches some of it went to the mice that were already 20 months of age so we wouldn't have to throw them out and then we executed we gave the rest to the young mice that had been produced in uh the following year expecting that the old mice it would fail the young mice it might work and as you know it worked well in both ages”

“fast forward to 2009 and um a very wellone study is published as part of the interventions testing program that looks at the use of Ramy in a very well documented strain of mice that are far more representative of what happens in biology than the typical strain of mice that are used in a clinical research setting you know the rest is history basically that study showed more convincingly than any other study in the ITP history that Rapa extended life in male mice in female mice and most importantly when initiated very late in life a period of time in which No Other Drug had ever been able to extend life”

“the ITP very consistently um even you know whether you talk about its home run drugs like rapy um and Other Drugs like recently 17 Alpha estradiol um they they disproportionately favor the male mice over the female mice”

“And without exception, every single ITP study of rapamy, whether they started in old mice or young mice, RAPA alone, RAPA with another drug, it just doesn't matter. It always worked.”

“Rapamycin was the drug that emerged as being robust and reproducible at all three sites where these experiments were conducted in mice.”