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Weekly · Sunday Morning

Five longevity claims.
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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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I Made Myself Older By Mistake — Whalespan

Content›Video›I Made Myself Older By Mista…

I Made Myself Older By Mistake

Bryan Johnson8m · 2025-03-31

Claims Made

14

Claims Supported

2

Support Rate

14%

Support rate

2 of 14 claims supported

2 supported12 partial / not

Claims from this content

12

✓Well SupportedEncapsulated rapamycin was effective in extending lifespan in both late middle-aged and younger mice.✕Not SupportedBryan Johnson stopped taking rapamycin after four years due to negative effects on lipids, blood glucose, resting heart rate, and small tissue infections.◐Partially SupportedPrior to recent research, rapamycin's only known human application was for immune suppression in organ transplant patients.✓Well SupportedRapamycin's anti-aging effect is proposed to be through inhibition of mTOR, which stimulates autophagy and may suppress senescent cells.Not Supported

More from Bryan Johnson

Bryan Johnson's Blueprint Rapamycin Protocol

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

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Rapamycin's inhibition of natural killer cells raises concerns about anti-cancer immune surveillance and increased cancer risk.

◐Partially SupportedRapamycin's effects on the immune system can be beneficial or detrimental for cancer, depending on dose.

◐Partially SupportedA pre-print evaluating longevity interventions showed that rapamycin accelerated biological aging in humans across 16 epigenetic clocks.

◐Partially SupportedRapamycin inhibits mTORC2, which is linked to metabolic side effects like high cholesterol, tissue swelling, soft tissue infections, and impaired wound healing.

◐Partially SupportedEating fast food or going to bed late are known risks that accelerate aging and cause metabolic disruption.

◐Partially SupportedNatural methods to inhibit mTORC1 include caloric restriction, fasting, exercise, and activators, whereas rapamycin inhibits mTORC1 directly.

◐Partially SupportedThe speaker is observing data on rapamycin's effect on aging and seeks data that could refute findings of accelerated aging.

◐Partially SupportedScience and data can determine which interventions slow or accelerate aging.