Andrew Huberman· PhD
MDMA works on the pitcher side of just basically throwing out more of the natural, the endogenous-
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
MDMA works on the pitcher side of just basically throwing out more of the natural, the endogenous-
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earlier we talked about MDMA as a drug that potently increases dopamine and even more potently increases serotonin largely acting through this serotonin 1B receptor
it's not just an issue of raising the levels of one neurochemical it's really about raising levels of a particular neurochemical acting in particular receptors in particular brain areas and in the case of MDMA the fact that there's also dopamine increased in those very same brain areas
what they find is that it really is the activation of the serotonin 1B receptor in the nucleus of Commons by MDMA that leads to this pro-social effect of MDMA
it showed very convincingly that it's serotonin released in the nucleus accumbens that's responsible for the prosocial effects of MDMA