Rimonabant blocks the endocannabinoid pathway, which is responsible for inducing hyperphagia when stimulated by THC, 2-AG, or anandamide.

“what Ramona band does is block the endocannabinoid pathway which is you know so we're all familiar with this term from pot smoking called the munchies right so THC is a drug the endocannabinoid pathway is so named because it's similar to the chemicals that affect it were first discovered from research in pot cannabis right so romanovan blocks that pathway so if you inject an animal with THC from marijuana or with these Hume these natural endocannabinoids primarily 2ag and anandamide um so you take a rat you feed it so it doesn't want to eat anymore and then you inject these chemicals into its brain it will immediately start eating again and regardless of what level of satiation it had reached right so they literally induce what's called hyperphagia overeating”