Illicit drugs and dopamine D2 receptor blockers increase or decrease dopamine non-selectively across major dopaminergic pathways.

“Now, this is also true if you rely on illicit drugs to increase dopamine. So if it's cocaine or methamphetamine, those will greatly increase dopamine but nonselectively across all those different pathways. And likewise with any drugs that inhibit or block or antagonize as it's called dopamine. This is why people who, for instance, have schizophrenia and take drugs to suppress auditory hallucinations, some of those drugs work because they block the so-called D2 receptor of the dopamine pathway.”