Andrew Huberman· PhD
Now, the trick here or the problem is that most of these drugs, especially in the 1950s and '60s, they would reduce serotonin but they would also reduce dopamine or they would increase serotonin, but they would also increase some other neuromodulator chemical. [...] This is most salient in the example of some of the antidepressants that have sexual side effects or that blunt appetite or that blunt motivation. You know, many of these which increase serotonin can be very beneficial for people. It can elevate their mood. It can make them feel better. But they also if their, the doses are too high or if that particular drug isn't right for somebody that person experiences challenges with motivation or appetite or libido because serotonin is binding to receptors in the areas of the brain that control those other things as well.