Andrew Huberman· PhD
part of the critical role of ketamine in providing relief from depression is to activate the opioid system
The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
part of the critical role of ketamine in providing relief from depression is to activate the opioid system
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what they observed is that when people were given ketamine got relief from depression that wasn't surprising again many studies had shown that before since the early 2000s if however individuals were given now treone to block the opioid receptor pathway and they were given ketamine well then the anti-depressant effects of ketamine were no longer observed