Adding a gene for corrected beta-hemoglobin to cells that already produce sickle-hemoglobin could potentially create more problems by increasing total hemoglobin levels while still retaining the sickling issue. — Whalespan
Adding a gene for corrected beta-hemoglobin to cells that already produce sickle-hemoglobin could potentially create more problems by increasing total hemoglobin levels while still retaining the sickling issue.
⚠ High risk
We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
✕NOTSUPPORTED
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High-risk intervention — consult a physician before acting.Drug-drug interactions, dose-dependence, and screening contraindications apply.
“would you actually run into a problem now where you're making too much hemoglobin and half of it is appropriate and half of it is Sickle and therefore not and you could argue you're creating more problems because you've doubled the hemoglobin but you still have the issue where the cells sickle and create all of the distal esia that the person has”