Ketamine binding to opioid receptors can produce pain relief, psychic state changes, dissociation, euphoria, and anesthesia at high doses.

“ketamine can bind to various opioid receptors and when opioid receptors are bound we know that creates certain effects things like pain relief things like changes in psychic States dissociation for example if enough of them are bound you can get euphoric States under certain conditions of high dose binding of ketamine to those opioid receptors you can start getting into plain of anesthesia where people lose Consciousness and actually have no response to pain whatsoever”