Peter Attia· MD
we saw and we measured seven of the 23 antigens wait tell me why that would be that's not an obvious purview into autophagy to me so let's back that up a little bit so you're giving them a pneumococcal vaccine which is what type of vaccine that's a polysaccharide antigen polysaccharide antigen you're not giving back the whole bacteria and how does it get presented to the immune system there are specific elements of innate immunity that recognize bacterial polysaccharide antigens and that brings it to professional antigen presenting cells likely dendritic cells and then it has to be internalized and then presented so that's mhc class one this isn't a peptide presentation this is presented in the context of an innate element that recognizes polysaccharide antigens okay all right so we're outside of class one class yes yes and you're saying the ability to internalize or basically the ability to phagocytose that like the polysaccharide and then and directly stimulate b cells yeah it was an exploratory element of the study we saw in the seven specific antigen responses we measured if i recall six of them increased but by a small amount it was a encouraging trend but we didn't further follow it up