Physiological dependency in patients treated with ketamine for indications like recalcitrant depression is very low.

“Ketamine is so just like to take a step back, ketamine is very different than the classical psychedelics. So, it's working on the NMDA receptor as opposed to the serotonin receptor. So all your classical psychedelics are work on the serotonin 2a receptor and that that includes DMT, LSD, psilocybin, um even MDMA works a little bit on that receptor although it also hits dopamine but all of the like 5 DMT all the classical psychedelics are working on that serotonin receptor whereas ketamine is working on NMDA. So ketamine can be addictive. It's minimally addictive. It's more like psychologically addictive than it is truly physically addictive, right?”