Ketamine dosages of 1-2 mg/kg induce anesthetic effects by saturating NMDA and opioid receptors.

“When you start getting to dosages of ketamine that are in the range of one at 2 milligram per kilogram of body weight now you're talking about anesthetic Doses and when that happens you're going to get full parking full saturation of all the potential receptors that ketamine can bind to those nmda receptors it's going to block those it's also going to bind to the so-called mu opioid receptors and maybe this other type as well for those of you that want to know u aisian a also the Kappa type opioid receptors”