Dopamine receptor blockade can alleviate schizophrenia symptoms, and L-dopa can induce psychotic symptoms in individuals without Parkinson's or schizophrenia.

“The the most conspicuous feature of schizophrenia is the fact that blocking dopamine receptors turns the symptoms down a little bit. We discovered that a long time ago. It was it was very early on seen as a hyperdopamineergic state. And it is that I mean it is that if you block dopamine receptors, you don't hear voices anymore. If you take uh L-dopa and you don't have Parkinson's and you don't have schizophrenia, I can find a dose where you will start to hear voices. I I can find a dose where you will start to feel paranoid. I can make you schizophren.”