Peter Attia· MD
so we basically took advantage of that it was a generian approach if you will an edward gender-like approach i mean edward jenner basically used the cal virus to protect against human smallpox stars so calp smallpox essentially cowpox would protect against human smallpox because they were energetically related enough that immunization with one could protect you from a disease caused by another that was our approach so and that was our initial approach was just to take a cal virus a calf virus that would cause diarrhea adapt it to growth in cell culture and then use that as our vaccine and it did work but it was inconsistent so then we had to modify that calf virus so that it included the genes that coded for the proteins that evoke what we found were neutralizing antibodies there were two surface proteins of the virus and we thought both independently evoked neutralizing antibodies that's what we proved so then it was a matter of just constructing these combination virus so called reassorted viruses between calf and animal strains that became the vaccine