High doses of stimulants can hypersimulate mitochondria, leading to reactive oxygen species production and subsequent damage.

“when you overdo it what happens is that if you hypers stimulate mitochondria with high doses of stimulants the mitochondria are essentially running on all cylinders and electrons start leaking out of the electron transport chain and what happens is that that creates reactive oxygen species which then damage the mitochondria themselves and damage other aspects of the cell and it can lead to Chronic mitochondrial disfunction chronic metabolic dysfunction”