Estrogen-only therapy (Premarin) in post-hysterectomy women in the WHI study was associated with a decreased risk of breast cancer and decreased breast cancer mortality.

“the women who were randomized to estrogen had no increased risk of breast cancer in fact if you want to be a stickler and play the same game my recollection is those women had a hazard ratio of 0.7 nine and the confidence interval ended up at one point zero one to translate that into English the women who were on estrogen only had a 21% risk but the 95% confidence interval crossed unity which meant it was not statistically significant the p-value is point zero seven”

“conjugated estrogen alone was associated with a significant Advocate a statistically significant reduction in breast cancer mortality so really diametrically opposite effects of the combination with the medroxy progesterone acetate of the estrogen with the hydroxyprogesterone acetate versus the conjugated estrogen alone”