Andrew Huberman· PhD
But you have, gosh, Salvinorin A, which is a kappa-opioid agonist, which again- - Where does that come from? - Salvia divinorum, it's a plant that became... 20 years ago, it sort of popped onto the legal high scene, and there's a long history of this predating the internet, going back to like the stuff one could order in the back of "High Times Magazine", and most of this stuff never worked, you know? [laughs] Or it's like, just smoke enough of anything, maybe you get a little bit lightheaded. But this is one of those things that popped around 20 years ago, when it quickly got the reputation of like, holy shit, this stuff actually works, and works really strongly. In these smoked extracts particularly, people have these reality-altering experiences on par with smoked DMT, the classic psychedelic.