Amphetamine and methamphetamine are destructive to dopaminergic neurons.

“But in addition to that seems to destroy dopaminergic neurons from time to time, I've talked about nicotine on here, not smoking because obviously smoking is bad lung cancer's bad for health, et cetera, but nicotine in supplemental form I've mentioned that a very famous neuroscientists Nobel prize winning scientists choose a lot of Nicorette. I know other people that you Nicorette they believe in its neuroprotective effects for Parkinson's and Alzheimer's and indeed nicotine can stimulate dopamine release. We talked about that earlier whether or not it has a protective effect isn't clear the protective effects might be through the noradrenergic and acetylcholine systems. Those findings are still unclear but it is interesting to note that nicotine can increase prolactin. Somewhat. There are a couple of studies I'd be happy to link to them in the caption that shows that nicotine taken too much over too long periods of time can also increase prolactin which again is the opposite side of dopamine.”