The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
When you increase serotonin in your brain because you won't let it be vacuumed out by the normal mechanisms that clear it from your brain, then it has the opportunity to be there longer and it has the opportunity to go into the dopamine terminals. This is something we know. The the mechanisms that suck dopamine out of the spaces of your brain um will also bind to serotonin and suck it out. Not quite as well because it's tuned. It's called a dopamine transporter.
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A killer paper 20 years ago on that where they showed they gave rodents um some common SSRI they waited this number of weeks and they went in there to say where is the serotonin. And what they showed was that the dopamine transporter pathway was the thing that was taking it into the dopamine terminals because that's where the dopamine transporters are.
This paper by John Danny in 2005 showed it goes into the dopamine system. And he knows that because he could block the dopamine reuptake. And you and it was a 40% difference.
And then it lowers the rewarding properties of good stuff. That's the best way to explain it. And you know, it's science. Somebody doesn't think that's the explanation. But the fact is, when you put an SSRI on, the serotonin that's released due to activity in serotonin neurons, it's not going back into serotonin terminals. Where does it go? This paper by John Danny in 2005 showed it goes into the dopamine system. And he knows that because he could block the dopamine reuptake. And you and it was a 40% difference.