Ketamine is a potent NMDA receptor antagonist that can block neuroplasticity in the short term and expand it in the long term.

“So you may have noticed a theme, which is that certain categories of approaches that we've been discussing for offsetting the symptoms of depression, such as exercise, ingesting EPAs, reducing inflammation, or even the SSRIs for increasing serotonin, focus on changing some core biological function, like raising the amount of a chemical, serotonin, or reducing the amount of inflammatory cytokines in the brain and body. And yet things like ketamine focus more on rewiring circuitry, changing neural circuitry so that it functions better in the immediate and hopefully in the long-term as well, and keep people with major depression in what they call, remission, away from major depression.”

“ketamine and PCP same thing and I learned about PCP as the compound that was going to make criminals like punch light poles and beat up 12 cops and yeah I watched too much chips when I was growing up for those of you old old enough to remember is like Ponch and John they the motorcycles with the shorts my sister watched it too but for completely different reasons so PCP was like this demonized drug but ketamine and all this stuff about ketamine is now legal in the US I don't know its status here in Sydney so I'll see if I get arrested on the way out but you know ketamine is potentially addictive people talk about the khole ETC weird name by the way um the whole business with ketamine is again it's a potent MDMA n methylaspartate blocker which blocks neuroplasticity in the short term expands it in the long term”