Tachyphylaxis means the body adjusts to compounds, leading to withdrawal symptoms upon cessation.

“tachyphylaxis with these compounds and by that that's a technical term that i will clarify means like the body does adjust you know if you give the body metoprolol or a beta blocker if you give the body a pharmaceutical molecule from a plant generally uh one of these compounds the body will adjust we see this with caffeine right it's an adenosine receptor antagonist and the body certainly changes the way it does things with cyclic amp and that's why people get withdrawal when they stop it so there is a tachyphylaxis effect”