NSAIDs like Tylenol, Advil, and Naproxen can lower body temperature and are sometimes used by endurance athletes to reduce core temperature during exertion.

“One of the more commonly used compounds that's sold over the counter are non-steroid anti-inflammatories so things like Tylenol and Advil and other trade names and Neproxin sodium things of that sort, almost all of those drop body temperature to some extent. And that's why it's often recommended that people take them when they have a fever... Now, a number of athletes especially endurance athletes will rely on these non-steroid anti-inflammatory drugs specifically to keep body temperature lower during long bouts of exertion.”