The CB1 receptor is primarily involved in the central nervous system effects of cannabis, while the CB2 receptor is mainly expressed on immune cells and regulates inflammation.

“so the receptor that's in the brain and throughout the body the CB1 and there is also a CB2 receptor it's not really expressed in the brain it's in some of the immune cells in the brain and maybe maybe some limited distribution in um actual brain cell neurons where where in the body is it it's mostly immune cells so you'll see CB2 is mostly on like macroasia or other kind of immune cells cells that gobble up debris yeah and that basically you know regulate inflammatory processes and so the main role of CB2 seems to be much more about like regulating inflammation um so that's kind of a separate role that can certainly impact the brain in different ways but uh when we talk about the effects on the central nervous system and the brain and behavior we're talking almost entirely about CB1”