Rimonabant was discontinued due to suicide risk, indicating CB1 receptor signaling is necessary for mental health. — Whalespan
Rimonabant was discontinued due to suicide risk, indicating CB1 receptor signaling is necessary for mental health.
⚠ High risk
We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
✕NOTSUPPORTED
⚠
High-risk intervention — consult a physician before acting.Drug-drug interactions, dose-dependence, and screening contraindications apply.
“now unfortunately it had the additional effect of making people want to kill themselves and I guess rats and cages don't really have opportunities for suicide so that effect was missed although they did in some of the human trials uh not include people with depression as candidates so they probably could have caught this one if they'd wanted to they were certainly aware of it but anyway”
“The problem came later when rimonabant for the prevention of cardiovascular events, this is the CRESCENDO trial, was published in 2010. And if you look at this trial, you will see they said that at a mean follow-up of 13.8 months, the trial was prematurely discontinued because of concerns by health regulatory authorities in in three countries about suicide in individuals who were receiving rimonabant.”