Low-dose phosphodiesterase-5 inhibitors may have been used by athletes to increase blood flow to muscles and the brain, and by cyclists to improve circulation and reduce negative effects of prolonged saddle pressure.

“Before the last Super Bowl there was some press about the fact that a lot of the players were taking these drugs at low dosages before the game presumably to increase blood flow to their muscles and brain is that is that what the rational was I think so yeah you know another we talked about sort of how cycling may lead to erectile problems or sexual problems there has been some data looking at taking like biago or one of these medications the AL to alil before a ride again to try and increase circulation to decrease the chance of any of the negative effects of prolonged saddle pressure”