The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
Anyways, he had put some studies in front of me that showed basically binding of either dynorphin or whatever ligand to the kappa opioid receptor basically sensitizes the mu opioid receptor to the feel-good endorphins and also changes, I think it also upregulates it or something, so, basically, there's a lasting effect of feeling good.
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
He was telling me about how agonism of the kappa-opioid receptor had a feedback loop effect where it actually caused mu-opioid receptors which bind to beta-endorphins to become more sensitized to the endorphins. And so I read up on this, checked the literature and references, and found that indeed the agonism of it does actually cause mu-opioid receptors to become sensitized to endorphins and I thought that was very interesting.