Andrew Huberman· PhD
the dosage used in that study as you recall was half a milligram per kilogram of body weight that is the dosage that will induce these dissociative mild Euphoria those sorts of states of mine but where people are still conscious
The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
the dosage used in that study as you recall was half a milligram per kilogram of body weight that is the dosage that will induce these dissociative mild Euphoria those sorts of states of mine but where people are still conscious
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what they found is that when they injected patients with severe depression with ketamine the effects of ketamine took place within minutes within 10 or 15 minutes and that they experienced a sort of Peak euphoric State okay so they're not inducing deep anesthesia right at this dosage they're getting people into a kind of euphoric dreamy semi- dissociative state that occurred within 15 minutes and really peaked about 45 minutes to an hour after they were injected with the drug and that the total effects of the drug in terms of euphoria were effectively over by about 2 hours or so
so not an iv push but a pretty quick drip yeah so really quick like mild dissociation i would say from my experience of using different doses and some kind of peripheral subjective changes