Endocannabinoids can facilitate synaptic strengthening by turning off inhibitory components and weaken synapses at the excitatory terminal.

“and so this can be really important for things like forms of synaptic plasticity or or neuroplasticity let's say where you want synaptic strengthening to happen so like under a learning event or something you want that synapse to really hardwire better and so having endoc canabo kind of turn off the inhibitory component is one of the mechanisms to facilitate that but at the same time if you want to have a bit more adaptive flexibility endoc canabo can weaken that synapse at the same time by acting right at the excitatory terminal itself”