MDMA's primary molecular targets are the serotonin and dopamine reuptake transporters.

“As you pointed out, MDMA, its major molecular targets, don't want to get too technical here, are the serotonin vacuum cleaner, the molecule that vacuums up serotonin, and the dopamine vacuum cleaner, the molecule that vacuums up, and, excuse my language, sucks up dopamine when it's released, because it's an amphetamine derivative, as you correctly pointed out, it not only prevents these proteins, we call them, these molecules, these vacuum cleaners,”

“What MDMA does is it actually calls what's known as a reverse transport. It not only prevents the vacuum cleaners from sucking up the dopamine and serotonin, it causes it to spew out dopamine and serotonin.”

“MDMA, its major molecular targets, don't want to get too technical here, are the serotonin vacuum cleaner, the molecule that vacuums up serotonin, and the dopamine vacuum cleaner, the molecule that vacuums up, and, excuse my language, sucks up dopamine when it's released, because it's an amphetamine derivative, as you correctly pointed out, it not only prevents these proteins, we call them, these molecules, these vacuum cleaners, from vacuuming up the dopamine and serotonin when it's released, it actually causes it, how do I, I don't want to use the terms to vomit out dopamine and serotonin”