Clinical holds for simian adenovirus vaccines were due to neurological issues like multiple sclerosis and transverse myelitis.

“the two clinical holds that were for the replication of active simian adenovirus which was the uk astrazeneca vaccine were both because of neurological issues the first was so-called undiagnosed multiple sclerosis the second was transverse myelitis which is an inflammation of a segment of the spinal cord the mechanism by which both of those diseases happen is the same which is that you make an immune response really to the sheathing of your nerves and particularly one protein on this evening of your nervous modeling basic protein”